In The First Descendant, crafting and upgrading Descendants, weapons, and modules depends heavily on a steady supply of materials. Among the most commonly required resources are Organic and Inorganic materials. These two categories form the backbone of progression, especially as you move from early-game crafting into mid- and late-game optimization.
Many players struggle not because the materials are rare, but because they don’t know where to farm them efficiently or which activities provide the best return for their time. This guide breaks down what Organic and Inorganic materials are, the best locations to farm them, and practical tips to maximize your farming efficiency.
Understanding Organic vs Inorganic Materials
Before jumping into farming routes, it’s important to understand what these materials represent in the game.
Organic Materials
Organic materials usually come from living enemies, biological experiments, mutated creatures, or environments tied to natural growth. These materials are often used in:
- Descendant crafting and research
- Skill-related upgrades
- Certain weapon and reactor components
They tend to drop from enemies rather than static objects.
Inorganic Materials
Inorganic materials are tied to machines, structures, minerals, and artificial constructs. You’ll typically use them for:
- Weapon crafting and enhancement
- Modules and reactors
- Structural components for research
These are more commonly obtained from mechanical enemies, destructible objects, or mission rewards.
Both types are required in large quantities, so efficient farming routes are essential.
Best Places to Farm Organic Materials
1. Kingston – Early-Game Organic Farming
Kingston is one of the first major zones players encounter, and it remains relevant for Organic farming even later.
Why Kingston works:
- High density of biological enemies
- Fast-clear missions
- Low difficulty allows quick farming
Recommended activities:
- Extermination Missions: These spawn large numbers of humanoid and mutated enemies.
- Field Events: Random events in Kingston often spawn waves of enemies, increasing drop chances.
Tips:
- Use area-of-effect skills to clear groups quickly.
- Run missions on repeat rather than roaming aimlessly.
Kingston is ideal if you’re new or need Organic materials for early research.
2. Sterile Land – Balanced Organic Farming
Sterile Land introduces stronger enemies and more consistent material drops.
Why Sterile Land is efficient:
- Enemies have higher drop rates than Kingston
- Mix of organic and semi-mechanical enemies
- Good XP alongside materials
Recommended activities:
- Void Intercept–style missions
- Defense and Survival missions
These missions spawn enemies continuously, which increases the number of Organic drops per run.
Tip:
Stay for the full duration of wave-based missions instead of leaving early. The longer you survive, the better the material yield.
3. Vespers – Mid-Game Organic Hotspot
Vespers is one of the best zones for pure Organic farming once you’re comfortable with stronger enemies.
Why Vespers stands out:
- High concentration of mutated and biological enemies
- Frequent elite enemies with better drop chances
- Missions are compact and fast-paced
Best farming method:
- Extermination and Capture Missions
These missions can be completed quickly, making them ideal for repeat farming.
Advanced Tip:
Equip Descendants with crowd-control or damage-over-time abilities. These shine in Vespers due to enemy density.
Best Places to Farm Inorganic Materials
1. Kingston – Beginner Inorganic Farming
While Kingston is more known for Organic materials, it still offers reliable Inorganic drops from:
- Mechanical enemies
- Destructible structures
- Mission rewards
Best activities:
- Sabotage Missions
- Outpost Objectives
These missions often involve destroying devices or fighting robotic enemies, which drop Inorganic materials more frequently.
2. Echo Swamp – High Inorganic Yield
Echo Swamp is one of the most efficient zones for farming Inorganic materials.
Why Echo Swamp is excellent:
- Heavy presence of mechanical and armored enemies
- Large number of destructible environmental objects
- Consistent mission rewards
Recommended missions:
- Defense Missions
- Facility Assault Missions
These missions force you to fight waves of robotic enemies, significantly boosting Inorganic material gains.
Tip:
Bring a Descendant with strong single-target damage for elite mechanical enemies, as they tend to drop better materials.
3. Agna Desert – Late-Game Inorganic Farming
Agna Desert is a tougher zone but offers some of the best Inorganic farming opportunities.
Why farm here:
- High-tier mechanical enemies
- Increased drop rates compared to earlier zones
- Excellent synergy with weapon XP farming
Best missions:
- Annihilation Missions
- High-Difficulty Operations
These missions reward Inorganic materials both from enemy drops and completion bonuses.
Advanced Tip:
Running these missions in a group increases clear speed and overall efficiency, especially against tanky enemies.
Farming Through Special Operations and Intercepts
Beyond open-world zones, some of the best material farming comes from instanced content.
Void Intercept Battles
Void Intercepts often drop:
- Large bundles of Organic and Inorganic materials
- Bonus crafting resources
While more challenging, they are worth running daily if you can clear them efficiently.
Special Operations
Special Operations are ideal because:
- They spawn continuous enemy waves
- They reward materials at set intervals
- They scale well for both solo and co-op play
Staying longer in these missions generally equals more materials.
Optimizing Your Farming Efficiency
Use the Right Descendant
- AoE-focused Descendants excel at Organic farming.
- High burst damage Descendants are better for Inorganic-heavy zones with elite enemies.
Stack Farming Buffs
If available, use:
- Drop-rate boosters
- XP boosters that indirectly improve efficiency
- Module setups focused on cooldown reduction and survivability
Repeat Short Missions
Short missions with high enemy density are almost always better than long, spread-out objectives.
Play in Co-op
Co-op farming:
- Clears missions faster
- Increases enemy spawn rates in some content
- Makes higher-tier zones more manageable
Organic vs Inorganic: Which Should You Farm First?
For most players:
- Early game: Focus on Organic materials for Descendant research.
- Mid game: Balance both, as weapon upgrades demand Inorganic materials.
- Late game: Inorganic materials become more important due to high-end weapons and modules.
Keeping a balanced stockpile prevents progression bottlenecks.
Farming Organic and Inorganic materials in The First Descendant isn’t about grinding endlessly—it’s about choosing the right locations, right missions, and right playstyle. Kingston and Sterile Land are perfect for beginners, while Vespers, Echo Swamp, and Agna Desert provide the best returns for experienced players.
By focusing on high-density missions, using efficient Descendants, and taking advantage of Special Operations and Void Intercepts, you can dramatically reduce the time spent farming and spend more time enjoying the game’s combat and progression.